Basic Information
VIS ID
TVIS44032795
Fusion event
HTLV-1-ASTN2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr9
Cytoband
q33.1
Reference genome
NCBI36/hg18
Start
118885228/117083128 (Hg38)
End
118885228/117083128 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9E ; FRA9B
Target gene
ASTN2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-526b-5p ; hsa-mir-1253 ; hsa-mir-591 ; hsa-mir-6761-5p ; hsa-mir-5571-5p ; hsa-mir-6880-5p ; hsa-mir-8085 ; hsa-mir-6746-5p ; hsa-mir-6731-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-6077 ; hsa-mir-766-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6760-5p ; hsa-mir-4419a ; hsa-mir-4779 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6770-5p ; hsa-mir-124-5p ; hsa-mir-6867-5p ; hsa-mir-5195-5p ; hsa-mir-8485 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-3152-3p ; hsa-mir-1251-3p
Nearest miRNA
hsa-let-7a-1/Upstream/2873599; hsa-mir-12126/Downstream/3161851;
Nearest TSS
ENST00000422679/Upstream/395785; ENST00000450938/Downstream/131425;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/395640, chr9-CpG: 163/Downstream/329847
Upstream sequence
AGTTTGGAATAATATATTTATTCATGTGTCTATTTGTGAAATACACTCTCCCTTCCCTTTTTCCTCTGGCATGACTAGAAATTTCATAAGGAAATCCATC
Downstream sequence
CTATTGGTCTATTTCCCACCATATTCCTGGTCTTCAGCAAAGAGTCTCAGTGGAATTAGATATTCAGTAAACATTAGTTGATTATGCAAATAAAAAAAAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate