Basic Information
VIS ID
TVIS44032797
Fusion event
HTLV-1-PRKCA integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr17
Cytoband
q24.2
Reference genome
NCBI36/hg18
Start
61968823/66542243 (Hg38)
End
61968823/66542243 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRKCA
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-505-3p ; hsa-mir-193b-3p ; hsa-mir-92a-3p ; hsa-mir-17-3p ; hsa-mir-203a-3p ; hsa-mir-218-5p ; hsa-mir-371b-5p ; hsa-mir-6828-5p ; hsa-mir-1976 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-5196-3p ; hsa-mir-6821-5p ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-6514-3p ; hsa-mir-7977 ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-585-3p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6847-3p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-4486 ; hsa-mir-142-3p ; hsa-mir-150-5p
Nearest miRNA
hsa-mir-10226/Upstream/1720141; hsa-mir-1250/Downstream/244829;
Nearest TSS
ENST00000595228/Upstream/125389; ENST00000307139/Downstream/292874;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/238744, chr17-CpG: 48/Downstream/292725
Nearest cancer related gene
PRKCA(OG, No orient, 0)
Upstream sequence
AAGCATTTTCCCCTTAACTTTAAAATTATTACAGAGAGGCCTTAAGAAACTGTTCTGTATTAGATGGTGATTAAAATATGACCTTTTTCTTTCTTTATGC
Downstream sequence
TTAGGATTTTCACGATGTGGTTTGCAATTAATTTGTATGTGCACAGTCTTTGTGCTAGTTTCTGTGGACATACAGTGGTGCTACTTGGCCTTAAGAGCTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate