Basic Information
VIS ID
TVIS44033004
Fusion event
HTLV-1-COL23A1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
NCBI36/hg18
Start
177650857/178291250 (Hg38)
End
177650857/178291250 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
COL23A1
miRNAs that regulate target gene
hsa-mir-676-5p ; hsa-mir-4474-5p ; hsa-mir-8086 ; hsa-mir-4680-5p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-4714-3p ; hsa-mir-7151-3p ; hsa-mir-767-5p ; hsa-mir-5095 ; hsa-mir-4735-5p ; hsa-mir-1224-3p ; hsa-mir-6504-3p ; hsa-mir-501-3p ; hsa-mir-502-3p ; hsa-mir-4438 ; hsa-mir-32-3p
Nearest miRNA
hsa-mir-10397/Upstream/1661750; hsa-mir-1229/Downstream/1507028;
Nearest TSS
ENST00000502646/Upstream/25416; ENST00000521803/Downstream/15684;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/58324, chr5-CpG: 23/Downstream/10972
Upstream sequence
cctaggctctgtgcactaagccacgcggcTGCCAAACCAGACCCCGAACCTCACTCGAGAATGAGGCCACACGGGGAGGCAGCACCCGGCAGTCAGCGGC
Downstream sequence
CAGCACGATTTATACGTCCCAAGTATGAGCCAGGAGCCATGGGGGTAACTAACGGGACCAGTAGTGAGTGCAAGAGGCAAGAGCCCTGGCTCATGAATGT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate