Basic Information
VIS ID
TVIS44033016
Fusion event
HTLV-1-DNAJC11 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
p36.31
Reference genome
NCBI36/hg18
Start
6627826/6645179 (Hg38)
End
6627826/6645179 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
DNAJC11
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-26b-5p ; hsa-let-7b-5p ; hsa-mir-193b-3p ; hsa-mir-324-5p ; hsa-mir-218-5p ; hsa-mir-5196-5p ; hsa-mir-323a-5p ; hsa-mir-4747-5p ; hsa-mir-671-5p ; hsa-mir-6134 ; hsa-mir-4786-3p ; hsa-mir-6858-3p ; hsa-mir-4709-3p ; hsa-mir-3689d ; hsa-mir-6851-5p
Nearest miRNA
hsa-mir-12136/Upstream/215283; hsa-mir-101-1/Downstream/2221323;
Nearest TSS
ENST00000473358/Upstream/67; ENST00000432429/Downstream/23031;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/19399, chr1-CpG: 96/Downstream/56056
Nearest cancer related gene
DNAJC11(TSG, No orient, 0)
Upstream sequence
AATTTGTGCTGATAGCTGATCAGTGCAAAGGAGTGAGGGATTCCCAGCTGGGGAGACAGAGGGTGCAAGGATGCGTGGCTAGGGCGTGTGACTCTGTGGG
Downstream sequence
GAGATGGGTATCTGCCCTCCCACTAGCTCTGGGCATCTGCTGCACACAGGCCTTTAAGGCAGGGGTCACGGTCTGGCAGCCGCAGTGAGTGCACCATGAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate