Basic Information
VIS ID
TVIS44033095
Fusion event
HTLV-1-C2orf49 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q12.2
Reference genome
NCBI36/hg18
Start
105321524/105338635 (Hg38)
End
105321524/105338635 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
C2orf49
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-600 ; hsa-mir-5580-3p ; hsa-mir-6796-3p ; hsa-mir-5089-5p ; hsa-mir-548s ; hsa-mir-6807-5p ; hsa-mir-3926 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6720-3p ; hsa-mir-668-5p ; hsa-mir-4252 ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-3190-5p ; hsa-mir-1273g-3p ; hsa-mir-1295b-3p ; hsa-mir-3186-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/2906269; hsa-mir-10b/Downstream/3802855;
Nearest TSS
ENST00000437798/Upstream/1103; ENST00000415627/Downstream/24403;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/843, chr2-CpG: 96/Downstream/59786
Upstream sequence
tgcatttttaacgagcttgttgctggcccagaaagcatgctttgaccaccactgTCCTAAGGCAATACTTTCCAAAGTAATGGGCTTATGAATTCTCTGG
Downstream sequence
GAACGTTGTCCAAGAGAATCCTGGTAGTTTCCCCTACTTCTGAGCGAGTACGGGCTAAAAATAGATGAGTCTAATATACGAAAGAGAAGTAAAATGTGCT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate