Basic Information
VIS ID
TVIS44033100
Fusion event
HTLV-1-PLEKHA7 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
p15.2
Reference genome
NCBI36/hg18
Start
16769211/16791088 (Hg38)
End
16769211/16791088 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
PLEKHA7
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-210/Upstream/821467; hsa-let-7a-2/Downstream/1596699;
Nearest TSS
ENST00000527297/Upstream/993; ENST00000620945/Downstream/257;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/52249, chr11-CpG: 93/Downstream/133757
Upstream sequence
AGCCCCAGGGTCCCCCGCTCACCCTGGAATCCCCATTCACACACTGCCCCAGCTCCCGGTCTCGCTTCCTCTCGTCTGACTGCCGCTTGAGGCCCCGCAC
Downstream sequence
AGATGTGTGCCGGATGATGGTGGCCTCTCTTGGCAGAGGCGGCACAGCCGGGGGCTGGTCCTCTGGGCTGTAGAGTTCGGGGAGTGGGGGCCTGGGAGGT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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