Basic Information
VIS ID
TVIS44033104
Fusion event
HTLV-1-EML6 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
NCBI36/hg18
Start
54819876/54739235 (Hg38)
End
54819876/54739235 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2D ; FRA2H
Target gene
EML6
miRNAs that regulate target gene
hsa-mir-302c-5p ; hsa-mir-215-5p ; hsa-mir-3143 ; hsa-mir-192-5p ; hsa-mir-6759-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-543 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p
Nearest miRNA
hsa-mir-1301/Upstream/890030; hsa-mir-10b/Downstream/1243732;
Nearest TSS
ENST00000437798/Upstream/14693; ENST00000493997/Downstream/9169;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/13884, chr2-CpG: 129/Downstream/310184
Upstream sequence
attcttttgaaatatggttataaaaatagttttaatatgtaggtatatgttatatgtgcttctttattaacacatacaattaaaagttttagtagttctt
Downstream sequence
ataattactatgatttaaaagtagggatgaatatacctgatgtttgagatatctgcaacaaatgtaatgtgatatgaaaattctgtgttttaccagtcac
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate