Basic Information
VIS ID
TVIS44033167
Fusion event
HTLV-1-RASAL2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
NCBI36/hg18
Start
176616249/178380491 (Hg38)
End
176616249/178380491 (Hg38)
Orient
+
Location type
Intronic
Target gene
RASAL2
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-15a-3p ; hsa-mir-125b-5p ; hsa-mir-99a-5p ; hsa-mir-92a-3p ; hsa-mir-203a-3p ; hsa-mir-6867-5p ; hsa-mir-511-3p ; hsa-mir-5583-3p ; hsa-mir-129-5p ; hsa-mir-4639-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-136-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1351046; hsa-mir-1182/Downstream/297258;
Nearest TSS
ENST00000473358/Upstream/39020; ENST00000463079/Downstream/71946;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/285780, chr1-CpG: 49/Downstream/106173
Nearest cancer related gene
RASAL2(TSG, No orient, 0)
Upstream sequence
AACCAGTTGGTTGAATTTAATTCCATGTGTGAGTTAGAGGTAACTAGAAAATTTATTAATTTATTTTGTAttaaattgaactatatgaaattgctggtat
Downstream sequence
tttaccattttaatctaccaaaaaaaggcagttctatagggctgtacctaaTAGAGTCATGATTATAAGCACATGTGTCTATTGAGTGGGGGTAGGGGCA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate