Basic Information
VIS ID
TVIS44033176
Fusion event
HTLV-1-ROS1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
NCBI36/hg18
Start
117763938/117336082 (Hg38)
End
117763938/117336082 (Hg38)
Orient
-
Location type
Intronic
Target gene
ROS1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-33a-5p ; hsa-mir-300
Nearest miRNA
hsa-mir-10398/Upstream/10551862; hsa-mir-1202/Downstream/1732965;
Nearest TSS
ENST00000381078/Upstream/70508; ENST00000533950/Downstream/1258;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/64966, chr6-CpG: 113/Downstream/146252
Nearest cancer related gene
ROS1(OG, No orient, 0)
Upstream sequence
CAGAAATATTCTTATATGATTACATATTTTTAAATGAGCATTTGAAGTTTTTATTAGTGATGGATTTGATGAATTGGTGATAAGATTAACAATATATCTC
Downstream sequence
AACTTGAAACAAAATAAGTGATAAATGAAAATAAAGAAAACTATCATAAGTTTTGGAGCATTTTCCCTCCATTCtttttttcaaatttttttatttttag
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate