Basic Information
VIS ID
TVIS44033200
Fusion event
HTLV-1-RLF integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
p34.2
Reference genome
NCBI36/hg18
Start
40475461/40237202 (Hg38)
End
40475461/40237202 (Hg38)
Orient
-
Location type
Intronic
Target gene
RLF
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-181a-5p ; hsa-mir-96-5p ; hsa-mir-877-3p ; hsa-mir-182-5p ; hsa-mir-17-5p ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p
Nearest miRNA
hsa-mir-12136/Upstream/2147873; hsa-mir-101-1/Downstream/517153;
Nearest TSS
ENST00000473358/Upstream/75829; ENST00000468258/Downstream/8745;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/75262, chr1-CpG: 22/Downstream/20512
Upstream sequence
TACACATGCAACTTCCTTGGCTGTAAAAAGTTCTATTACTCCAAAATTGAATACCAGAATCACCTCTCAATGCATAATGTTGAAAATTCAAATGGAGACA
Downstream sequence
TAAAGAAATCAGTGAAACTTGAGGAGTCTGCAACAGGTGAAAAGCAAGATTGTATTAATCAGCCCCATCTACTTAACCAAACTGATAAATCACATTTACC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate