Basic Information
VIS ID
TVIS44033216
Fusion event
HTLV-1-SEL1L3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
NCBI36/hg18
Start
25467299/25856579 (Hg38)
End
25467299/25856579 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
SEL1L3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-19b-3p ; hsa-mir-93-3p ; hsa-let-7a-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-486-5p ; hsa-mir-339-5p ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-520f-5p ; hsa-mir-6780a-3p ; hsa-mir-6881-3p ; hsa-mir-7111-3p ; hsa-mir-1236-3p ; hsa-mir-877-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183
Nearest miRNA
hsa-mir-12113/Upstream/1336289; hsa-mir-1243/Downstream/2963003;
Nearest TSS
ENST00000502981/Upstream/77376; ENST00000522137/Downstream/4052;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/180069, chr4-CpG: 123/Downstream/5559
Upstream sequence
CAAATATGTTTATACCAGATGTGAGCCCTCATCAAAGTCAAATTTGACAACGTCATGCACAGTCACAAAACACAGATTCTCTTGCTTTTGTGTAAATGTG
Downstream sequence
CATGTATTGTAATTaaaaaaaaaaaaaaaaaaaacaaagaaaTGGGCCAGTTAATGTGTGTTCATGATAGAAGACCCCAAATAGGAGATCTAAATGCATT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate