Basic Information
VIS ID
TVIS44033223
Fusion event
HTLV-1-PRR5L integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
NCBI36/hg18
Start
36290582/36312456 (Hg38)
End
36290582/36312456 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11E
Target gene
PRR5L
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-502-5p ; hsa-mir-27b-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125
Nearest miRNA
hsa-mir-1343/Upstream/302252; hsa-let-7a-2/Downstream/7247200;
Nearest TSS
ENST00000527297/Upstream/11495; ENST00000532843/Downstream/10984;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/367552, chr11-CpG: 122/Downstream/63947
Upstream sequence
CAGGGGTTGTGTACTCGGAAGGTAAAGATCACCATCTCCATCTGTTAAACACAGCACTGCTGTGCTGTCTACATTTCACTCAGCAGGTGTGCTTTACACC
Downstream sequence
AAGTAGGTGCTTGGAAGTATGCCTGCTAAGGGCTGAGCCAGCCAGAGTGTTGTATGATCTGTTGGACCAGCTGTTCATTGCCACTCACTTgagaggtggt
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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