Basic Information
VIS ID
TVIS44033256
Fusion event
HTLV-1-PRKN integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
q26
Reference genome
NCBI36/hg18
Start
163014766/162673744 (Hg38)
End
163014766/162673744 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6E
Target gene
PRKN
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-3187-3p ; hsa-mir-1303 ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-483-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-10398/Upstream/3908991; hsa-mir-1913/Downstream/3835610;
Nearest TSS
ENST00000381078/Upstream/398358; ENST00000544266/Downstream/53388;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1027087, chr6-CpG: 75/Downstream/53600
Nearest cancer related gene
PRKN(TSG, No orient, 0)
Upstream sequence
taaagtgctgggattacaggcgtgagccaacacgcccagccTAGATTTTTTTTAAATGTAAATCAAAGTAAGAGAAAAAACCAAAACATCCAAACCATAC
Downstream sequence
AGAGGAAGATGGAAAATAACAGAATCAGGAACCTGAGCTCATGCCAACACTCAATCATACGTTCAAACTTTCTGTCAAGAAAGGCTACAGCAGGACTGCA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate