VISDB - VIS Detail

Basic Information

VIS ID

TVIS44033282

Fusion event

HTLV-1-CLOCK integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr4

Cytoband

q12

Reference genome

NCBI36/hg18

Start

56066462/55505538 (Hg38)

End

56066462/55505538 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA4B

Target gene

CLOCK

miRNAs that regulate target gene

hsa-mir-141-3p ; hsa-mir-182-5p ; hsa-mir-106b-5p ; hsa-mir-142-3p ; hsa-mir-26b-5p ; hsa-mir-21-5p ; hsa-mir-124-3p ; hsa-mir-152-3p ; hsa-mir-34a-5p ; hsa-mir-20a-5p ; hsa-mir-203a-3p ; hsa-mir-526b-5p ; hsa-mir-4635 ; hsa-mir-5571-5p ; hsa-mir-4423-3p ; hsa-mir-6826-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-3622a-5p ; hsa-mir-5582-5p ; hsa-mir-552-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-1290 ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-5583-5p ; hsa-mir-3129-3p ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-580-3p ; hsa-mir-4461 ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-129-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-107

Nearest miRNA

hsa-mir-12113/Upstream/2792791; hsa-mir-1243/Downstream/5417081;

Nearest TSS

ENST00000502981/Upstream/26478; ENST00000609234/Downstream/4489;

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/109202, chr4-CpG: 144/Downstream/40288

Upstream sequence

agatcgttagagctcaggagttcaagaccagcctgggcaacatggcaaaaccccttatctactaaaaatacaaaaattagctgggtgttgtggcacgtgc

Downstream sequence

ctatggtctcagctacttgggaagctgaggcaggaggatcaactaagccctggaagtccaggctgcaatgagctgtgactgcaccactgcactccaggct

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.