Basic Information
VIS ID
TVIS44033299
Fusion event
HTLV-1-GNAL integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
NCBI36/hg18
Start
11850412/11860413 (Hg38)
End
11850412/11860413 (Hg38)
Orient
-
Location type
Intronic
Target gene
GNAL
miRNAs that regulate target gene
hsa-mir-10a-5p ; hsa-mir-99a-5p ; hsa-mir-16-5p ; hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-3942-3p ; hsa-mir-6792-5p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6838-5p ; hsa-mir-759 ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-33a-3p ; hsa-mir-409-3p ; hsa-mir-489-3p ; hsa-mir-129-5p ; hsa-mir-6878-3p ; hsa-mir-6735-3p ; hsa-mir-329-5p ; hsa-mir-4761-5p
Nearest miRNA
hsa-mir-3976/Upstream/205472; hsa-mir-1-2/Downstream/1599534;
Nearest TSS
ENST00000575820/Upstream/2859; ENST00000586926/Downstream/11888;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/8290, chr18-CpG: 109/Downstream/47810
Upstream sequence
TGCCTCAGTTTTGGCCACTAGGGACTGTCTCTAGCTTTCCAAAAGGAAGGAGTTAAGATGTCCAAGGAAATTATGTAGTCTTACTGTCTTTGGCCAAGTG
Downstream sequence
GTTCCTAAAATGGACCCCTTTTGACCTCtgtagggaaggaaaaagaacttccctctttcccattaggttctgtagctgagtgaactaacaaagacggatt
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate