Basic Information
VIS ID
TVIS44033303
Fusion event
HTLV-1-LHX4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
q25.2
Reference genome
NCBI36/hg18
Start
178472038/180236280 (Hg38)
End
178472038/180236280 (Hg38)
Orient
-
Location type
Intronic
Target gene
LHX4
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-4313 ; hsa-mir-3605-5p ; hsa-mir-6832-3p ; hsa-mir-6894-5p ; hsa-mir-548s ; hsa-mir-3688-5p ; hsa-mir-3926 ; hsa-mir-4470 ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-548as-3p
Nearest miRNA
hsa-mir-101-1/Upstream/432255; hsa-mir-1182/Downstream/202034;
Nearest TSS
ENST00000473358/Upstream/5982; ENST00000561113/Downstream/12005;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/440, chr1-CpG: 92/Downstream/265910
Nearest cancer related gene
LHX4(TSG, No orient, 0)
Upstream sequence
AAAATCGAGTGCTCCTAGAGGTGGGGTGGGGGTGGGAGAGCCGGGAAACCAGCAAAGCAATTTCTTTCCATTGAGTAGACAAAAACTTGGGCCACAGGGG
Downstream sequence
CATCTTGTATTTTGAACAGTGACCCGATGACCCCGCTGGCCAGGTGTAGACAGCCTCAAGTCCTAAATATTTGCATTGTCCTAACTTCCCAGTTGCCTCG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate