Basic Information
VIS ID
TVIS44033310
Fusion event
HTLV-1-WWP2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
NCBI36/hg18
Start
68386023/69794619 (Hg38)
End
68386023/69794619 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
WWP2
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-23b-3p ; hsa-mir-26a-5p ; hsa-let-7a-5p ; hsa-mir-7109-5p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6795-5p ; hsa-mir-6887-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1268b ; hsa-mir-1237-5p ; hsa-mir-1268a ; hsa-mir-4731-5p ; hsa-mir-6853-5p ; hsa-mir-637
Nearest miRNA
hsa-mir-1225/Upstream/228751; hsa-mir-11401/Downstream/138462;
Nearest TSS
ENST00000527434/Upstream/18432; ENST00000567986/Downstream/4246;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/31953, chr16-CpG: 77/Downstream/170515
Upstream sequence
cccggtctcaaaaaaaaaaagaaactataaactaaatttctcccaaaattagcttggcccatgcccaggaatgaccaaggacagcctagaaatcagaagt
Downstream sequence
aagatggaatcaactatgtccgatttctctgtcataattttgcaaaggcagtttcacaattagaaaaatgtagaatttgctgcattctttaaaacagctg
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate