Basic Information
VIS ID
TVIS44033373
Fusion event
HTLV-1-IQGAP1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
NCBI36/hg18
Start
88739360/90395124 (Hg38)
End
88739360/90395124 (Hg38)
Orient
+
Location type
Intronic
Target gene
IQGAP1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-324-3p ; hsa-mir-92a-3p ; hsa-mir-376a-3p ; hsa-mir-544a ; hsa-mir-136-3p ; hsa-mir-3074-3p ; hsa-mir-449b-3p ; hsa-mir-506-3p ; hsa-mir-506-5p
Nearest miRNA
hsa-mir-10393/Upstream/388283; hsa-mir-1302-10/Downstream/2509275;
Nearest TSS
ENST00000557528/Upstream/6769; ENST00000559682/Downstream/2757;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/6337, chr15-CpG: 166/Downstream/134333
Upstream sequence
ACTGGGAAAATTTAGGGGTAATTCCTATAAATGAGCACTGGGAGTGGTTGAGAAATAGAAAATGTAGAGATTTCTGCTTTTCTTCATTGTTTGGAGAGCA
Downstream sequence
GCTTCAATATTGAAATTAAGCCGCTGTTCTAATGAGATATCACCTAACGATTCAAGGCTTTTTGCTAAGGGCTGCACAATAGATCAAGGATACATCTTAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate