Basic Information
VIS ID
TVIS44033384
Fusion event
HTLV-1-PLA2G4A integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
q31.1
Reference genome
NCBI36/hg18
Start
185088291/186852536 (Hg38)
End
185088291/186852536 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
PLA2G4A
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-30a-5p ; hsa-mir-146b-5p ; hsa-mir-10a-5p ; hsa-mir-449c-5p ; hsa-mir-7977 ; hsa-mir-3157-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4755-3p ; hsa-mir-342-3p ; hsa-mir-4691-3p ; hsa-mir-1228-3p ; hsa-mir-665 ; hsa-mir-6771-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-7160-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6746-5p ; hsa-mir-5690 ; hsa-mir-2114-5p ; hsa-mir-5588-3p ; hsa-mir-6783-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-2115-3p ; hsa-mir-4310 ; hsa-mir-4711-5p ; hsa-mir-4738-3p ; hsa-mir-548av-3p ; hsa-mir-7157-5p
Nearest miRNA
hsa-mir-101-1/Upstream/6414146; hsa-mir-1182/Downstream/5863792;
Nearest TSS
ENST00000473358/Upstream/23583; ENST00000466600/Downstream/1750;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/171587, chr1-CpG: 56/Downstream/5955966
Upstream sequence
aacagaatgtgacccactgggtaattaataaagtgaacaaatttattggcttacagttttggaagctgggaagtccaaggccaaggagccagcagttttg
Downstream sequence
gtgcctggtgaggctattcttttctttcaagatagccattgtccagaggagatgaaggctgtatctaaaatatggcagaaggcaaaagggctaagagaga
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate