Basic Information
VIS ID
TVIS44033396
Fusion event
HTLV-1-ELF4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chrX
Cytoband
q26.1
Reference genome
NCBI36/hg18
Start
129049035/130087379 (Hg38)
End
129049035/130087379 (Hg38)
Orient
-
Location type
Intronic
Target gene
ELF4
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-877-5p ; hsa-mir-615-3p ; hsa-mir-505-3p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-let-7f-5p ; hsa-mir-331-5p ; hsa-mir-4666a-5p ; hsa-mir-8068 ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-5087 ; hsa-mir-657 ; hsa-mir-3665 ; hsa-mir-298 ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-4678 ; hsa-mir-376c-3p
Nearest miRNA
hsa-let-7f-2/Upstream/8716326; hsa-mir-105-1/Downstream/4081999;
Nearest TSS
ENST00000429181/Upstream/5947; ENST00000257017/Downstream/22982;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/26651, chrX-CpG: 189/Downstream/22320
Nearest cancer related gene
ELF4(OG, No orient, 0)
Upstream sequence
CAGCCTAGGAGAGCCCCCAGAAGCCCCTGCAGATCCTAAGATCATCGGCTTTCCAGCTAGAAGCCCCAGCTCTGCCTTGGGGTTGAGGCAGGtcactttc
Downstream sequence
ctcttttgtaaaacagggatctcctatttagctcaaggggttgttgcaaaaggccaatgagctaatgtaggcaaaAGCTCTCTGTTAGCCCGAAACGTGt
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate