Basic Information
VIS ID
TVIS44033409
Fusion event
HTLV-1-MCOLN2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
p22.3
Reference genome
NCBI36/hg18
Start
85232501/84994230 (Hg38)
End
85232501/84994230 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
MCOLN2
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-601 ; hsa-mir-4641 ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-25-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-363-3p ; hsa-mir-365a-3p ; hsa-mir-365b-3p ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-1273f ; hsa-mir-1289 ; hsa-mir-129-5p ; hsa-mir-1304-3p ; hsa-mir-143-3p ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4534 ; hsa-mir-4708-5p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-6514-5p ; hsa-mir-8055 ; hsa-mir-8082
Nearest miRNA
hsa-mir-101-1/Upstream/7934028; hsa-mir-11399/Downstream/139564;
Nearest TSS
ENST00000473358/Upstream/64386; ENST00000528899/Downstream/2710;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/100726, chr1-CpG: 86/Downstream/2672
Upstream sequence
aaatattcagtaaatcatgctgtaaacaagtgtactgtcatctaggctttgttgttccatttacaaagcagaggcagagtagattaacataattcttaag
Downstream sequence
tgccctaggatttttggaatggtaaatgagcactggcttcaacttaaaagtcaccagctgtactagttcctaactagagagtcatcctgtcctttgcacc
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate