Basic Information
VIS ID
TVIS44033423
Fusion event
HTLV-1-TMEFF2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q32.3
Reference genome
NCBI36/hg18
Start
192673394/192100423 (Hg38)
End
192673394/192100423 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEFF2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-7641 ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6780b-3p ; hsa-mir-4780 ; hsa-mir-6512-3p ; hsa-mir-6720-5p ; hsa-mir-7106-3p ; hsa-mir-4252 ; hsa-mir-494-3p ; hsa-mir-6849-3p ; hsa-mir-4691-3p
Nearest miRNA
hsa-mir-10b/Upstream/2967312; hsa-mir-1244-1/Downstream/14682811;
Nearest TSS
ENST00000437798/Upstream/64253; ENST00000414394/Downstream/94101;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/218153, chr2-CpG: 140/Downstream/93846
Nearest cancer related gene
TMEFF2(TSG, No orient, 0)
Upstream sequence
TGGGCTTTCAGGAAAGTTTGACTTCAAATGTTATTTTCCAACAATCCTCTGTCATGTCACTGTGACCGAAGTCTTCTAGCATGCATTTTCAAAGCACATC
Downstream sequence
TTCTATACTTCCAACTTCTGGTTACTGCACTTAACCTTATCGAACAAAGGCTGTTTGGGTAGAATGACTATCTTCACTCACTACTACTGTGATACTTAGT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate