VISDB - VIS Detail

Basic Information

VIS ID

TVIS44033456

Fusion event

HTLV-1-IPMK integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr10

Cytoband

q21.1

Reference genome

NCBI36/hg18

Start

59690975/58261208 (Hg38)

End

59690975/58261208 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA10C

Target gene

IPMK

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-339-5p ; hsa-mir-1183 ; hsa-mir-6073 ; hsa-mir-6124 ; hsa-mir-20b-3p ; hsa-mir-4280 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-548g-3p ; hsa-mir-548n ; hsa-mir-142-3p ; hsa-mir-921 ; hsa-mir-3606-5p ; hsa-mir-1257 ; hsa-mir-4790-3p ; hsa-mir-203a-3p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-454-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-5680 ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p

Nearest miRNA

hsa-mir-1265/Upstream/956649; hsa-mir-107/Downstream/5111749;

Nearest TSS

ENST00000439456/Upstream/1899933; ENST00000489785/Downstream/6726;

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/154171, chr10-CpG: 188/Downstream/6039

Upstream sequence

AAAaaaaaaaaatgaggaggaactctatgaactgatacatacgaatttctaggatatagtcttaactcttaaaaaccatgtgaaaaacagtatatacagc

Downstream sequence

atactagattttgtatcagaaagaaagggaaataaaacttccatagatctatttaattctgtaaaaagaaactcaaaaagggtaaatcagaaaacaatga

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.