Basic Information
VIS ID
TVIS44033463
Fusion event
HTLV-1-SERPINB5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr18
Cytoband
q21.33
Reference genome
NCBI36/hg18
Start
59296036/63477823 (Hg38)
End
59296036/63477823 (Hg38)
Orient
+
Location type
Intronic
Target gene
SERPINB5
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-21-5p ; hsa-mir-335-5p ; hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-2115-5p ; hsa-mir-3185 ; hsa-mir-4762-5p ; hsa-mir-141-5p ; hsa-mir-5197-3p ; hsa-mir-7-5p ; hsa-mir-103a-3p ; hsa-mir-107
Nearest miRNA
hsa-mir-1-2/Upstream/5026665; hsa-mir-5011/Downstream/3603761;
Nearest TSS
ENST00000575820/Upstream/696; ENST00000588986/Downstream/8854;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/54699, chr18-CpG: 63/Downstream/458343
Nearest cancer related gene
SERPINB5(TSG, No orient, 0)
Upstream sequence
TCATATGCTGTACACTTTTTCTTATGGCTTCATTTAAGCATATCATACTAAAAACCAACATGCCAGGCTATTCCAGAGACTTGTAACCAGATCCtcagag
Downstream sequence
ctgggggctcttagacatatttcagcccagccccctcattctgtagatgaggagcagaactcacagaggtgatctggtgtccaaaggcacacagcttgta
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate