Basic Information
VIS ID
TVIS44033476
Fusion event
HTLV-1-CBL integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
NCBI36/hg18
Start
118588767/119212847 (Hg38)
End
118588767/119212847 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
CBL
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-let-7c-5p ; hsa-mir-150-5p ; hsa-mir-155-5p ; hsa-mir-98-5p ; hsa-mir-188-3p ; hsa-mir-218-5p ; hsa-mir-1273d ; hsa-mir-7973 ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-4287 ; hsa-mir-4685-3p ; hsa-mir-1224-3p ; hsa-mir-1306-5p ; hsa-mir-216a-5p ; hsa-mir-124-3p ; hsa-mir-1972 ; hsa-mir-3150b-3p ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4693-3p ; hsa-mir-4717-5p ; hsa-mir-4784 ; hsa-mir-5192 ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-10392/Upstream/302060; hsa-let-7a-2/Downstream/100103;
Nearest TSS
ENST00000527297/Upstream/6423; ENST00000634301/Downstream/85525;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/6003, chr11-CpG: 19/Downstream/97839
Nearest cancer related gene
CBL(TSG, No orient, 0)
Upstream sequence
cgcctgtaatcccagcactttgggaggctgaggctgggggatcacctgaggtcagcagtttgagaccagcctggccaacatggtgaaaccccgtctctac
Downstream sequence
caaaataccaaaattagctgagcatgatggcgggtgcctgtcctggctacaggaggcagaggttgcagtgagccaagatcatgctactgacctccagcct
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate