Basic Information
VIS ID
TVIS44033495
Fusion event
HTLV-1-PTPRT integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr20
Cytoband
q12
Reference genome
NCBI36/hg18
Start
40306945/42244891 (Hg38)
End
40306945/42244891 (Hg38)
Orient
-
Location type
Intronic
Target gene
PTPRT
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-331-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-16-5p ; hsa-mir-3928-3p ; hsa-mir-215-5p ; hsa-mir-3149 ; hsa-mir-630 ; hsa-mir-29a-5p ; hsa-mir-186-3p ; hsa-mir-664a-3p ; hsa-mir-5096 ; hsa-mir-197-3p ; hsa-mir-103a-2-5p ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-6809-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-4753-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6832-3p ; hsa-mir-515-3p ; hsa-mir-5581-5p ; hsa-mir-7702 ; hsa-mir-4297 ; hsa-mir-6747-3p ; hsa-mir-4524b-3p ; hsa-mir-3909 ; hsa-mir-4494 ; hsa-mir-4633-3p ; hsa-mir-4738-3p ; hsa-mir-4766-3p ; hsa-mir-4773 ; hsa-mir-499b-5p ; hsa-mir-6500-5p ; hsa-mir-6736-3p ; hsa-mir-6852-3p ; hsa-mir-6874-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/1075813; hsa-mir-1-1/Downstream/2163229;
Nearest TSS
ENST00000382410/Upstream/229413; ENST00000608258/Downstream/227671;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/245506, chr20-CpG: 173/Downstream/943944
Nearest cancer related gene
PTPRT(TSG, No orient, 0)
Upstream sequence
AATGAACACTTTCAACTATTGAGACATGCTGGTTAAGGCAATAATACTTGATCTTTTCATCTTAATTTGCATTAAAGGCACACAGTGCCCCATGGTATTA
Downstream sequence
AGTTAAGAAAACATAGAGTTGGTCATGCAACCTCTTGATTGCTGGTTTTGGAGGAGTGGGGAGGATGTCTAACAGTTCTAAGGGGAGGAGGCAAGGGACG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate