Basic Information
VIS ID
TVIS44033537
Fusion event
HTLV-1-PNPO integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr17
Cytoband
q21.32
Reference genome
NCBI36/hg18
Start
43375284/47942919 (Hg38)
End
43375284/47942919 (Hg38)
Orient
+
Location type
Intronic
Target gene
PNPO
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-18a-5p ; hsa-mir-382-5p ; hsa-mir-495-5p ; hsa-mir-421 ; hsa-mir-1252-3p ; hsa-mir-3121-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-6849-3p ; hsa-mir-2054 ; hsa-mir-376a-5p ; hsa-mir-4424 ; hsa-mir-4709-5p ; hsa-mir-4800-3p ; hsa-mir-3646 ; hsa-mir-6509-5p ; hsa-mir-548s ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4531 ; hsa-mir-3926 ; hsa-mir-139-3p ; hsa-mir-571 ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-370-5p ; hsa-mir-670-5p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-339-5p ; hsa-mir-6088 ; hsa-mir-143-3p ; hsa-mir-4770
Nearest miRNA
hsa-mir-1180/Upstream/969819; hsa-mir-10226/Downstream/89963;
Nearest TSS
ENST00000595228/Upstream/910; ENST00000584806/Downstream/2479;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/46031, chr17-CpG: 63/Downstream/27784
Upstream sequence
ggaggatgaggttggaggattgcttgagctcaggaagttgagactgcagtaagccgagatcacaccaccgcactccagcctaggtgacagagtgagaccc
Downstream sequence
tgtctaaaataaataaataaataaataaaAATGCAGTTTTTGATGAAGcctcagacctgctgaatgagaaattttgggggtggagcccagaaagtttttt
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate