Basic Information
VIS ID
TVIS44033564
Fusion event
HTLV-1-MAPK10 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
q21.3
Reference genome
NCBI36/hg18
Start
87501679/86361502 (Hg38)
End
87501679/86361502 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAPK10
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-574-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-6819-5p ; hsa-mir-6812-5p ; hsa-mir-6737-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-5002-5p ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-3152-3p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-mir-12113/Upstream/638969; hsa-mir-1243/Downstream/180980;
Nearest TSS
ENST00000502981/Upstream/1278; ENST00000507902/Downstream/9388;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/885686, chr4-CpG: 77/Downstream/232528
Nearest cancer related gene
MAPK10(TSG, No orient, 0)
Upstream sequence
TACCTCATGCAAAAATATGGATTGATAGCCAAACAACTTTATAACACAAAATAATTGGCATTCTGGCTTTTGAGGTATTATATACTAAGTTTGGACATCA
Downstream sequence
AAAGTCAGTTCCCCAatcccatggaaattaaatcagtttgtcgaagagatgtctgcattcccatatttattgcagcactattctaatagccatggaaaca
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate