Basic Information
VIS ID
TVIS44033567
Fusion event
HTLV-1-NRXN1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
p16.3
Reference genome
NCBI36/hg18
Start
50083754/50003112 (Hg38)
End
50083754/50003112 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
NRXN1
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-16-5p ; hsa-mir-616-5p ; hsa-mir-498 ; hsa-mir-1537-5p ; hsa-mir-302a-5p ; hsa-mir-3607-3p ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-574-5p ; hsa-mir-4752 ; hsa-mir-6867-5p ; hsa-mir-8056 ; hsa-mir-3691-5p ; hsa-mir-376c-5p ; hsa-mir-376b-5p ; hsa-mir-7114-5p ; hsa-mir-6818-5p ; hsa-mir-4320
Nearest miRNA
hsa-mir-1301/Upstream/943454; hsa-mir-10b/Downstream/693060;
Nearest TSS
ENST00000437798/Upstream/28909; ENST00000634985/Downstream/13433;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1247366, chr2-CpG: 74/Downstream/343791
Upstream sequence
TTTAGAGTCTGGGCCAAAAGATTTATAGGATTTGAGAAATGAGAAATAAGTTTTTCTCTCTTAGACAACTCCTATATAAAAGCAGTGGTTTTCGAGATAG
Downstream sequence
TTATGTTCTAAGGCTTGGTGGATGAGAATACCCTGATTAATTATGCATCAATATGGAATAGGGTCCATATATACCACTTCTGTCATTAGTCCCTTCTGTA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate