Basic Information
VIS ID
TVIS44033583
Fusion event
HTLV-1-TLL1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
q32.3
Reference genome
NCBI36/hg18
Start
167019991/165879389 (Hg38)
End
167019991/165879389 (Hg38)
Orient
+
Location type
Intronic
Target gene
TLL1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-6869-5p ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-15a-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-4482-3p ; hsa-mir-7159-3p ; hsa-mir-3924 ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-4773
Nearest miRNA
hsa-mir-12113/Upstream/493052; hsa-mir-1305/Downstream/5306795;
Nearest TSS
ENST00000502981/Upstream/4431; ENST00000503003/Downstream/646730;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/5200, chr4-CpG: 27/Downstream/2439009
Upstream sequence
CATCAGAAACCATATTGTCTTCCTCTATTGTGTATGCAGGAATCCTATTTTTGAACATCTTAGCAAATTTCTCTCATGTGAAATTGAGACTTACTTGCCA
Downstream sequence
ATAGTTAAAACAATATTCTTTGCAAACCTTCTTATGGCTATTAGTCACCTTAATCATCCTTCAGACCTTTCAATTATTGAGGCCTTGATATGATCGCTTA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate