Basic Information
VIS ID
TVIS44033587
Fusion event
HTLV-1-GOLPH3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
NCBI36/hg18
Start
32175091/32139228 (Hg38)
End
32175091/32139228 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
GOLPH3
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-320b ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-106a-3p ; hsa-mir-3529-3p ; hsa-mir-134-5p
Nearest miRNA
hsa-mir-10397/Upstream/203069; hsa-mir-103a-1/Downstream/255150;
Nearest TSS
ENST00000502646/Upstream/17287; ENST00000606994/Downstream/35074;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/283908, chr5-CpG: 124/Downstream/34264
Nearest cancer related gene
GOLPH3(OG, No orient, 0)
Upstream sequence
ATCATCTTGCCAATATAGTCGGCCttccatatctatagattcaaccaattgaggatcaaaaatatccaggaaaaataatacaaattttaaaatgcagtat
Downstream sequence
aacaattgtttatacagcatttacattgtattaggtattgtaagtaatctgggggtgacataaagtatagaagaggatgtgcataggttatatgcaaaca
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate