Basic Information
VIS ID
TVIS44033593
Fusion event
HTLV-1-TOM1L2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
NCBI36/hg18
Start
17691638/17847599 (Hg38)
End
17691638/17847599 (Hg38)
Orient
-
Location type
Intronic
Target gene
TOM1L2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-130b-3p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-3161 ; hsa-mir-8075 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-4728-3p ; hsa-mir-513b-3p ; hsa-mir-186-3p ; hsa-mir-5003-5p ; hsa-mir-3714 ; hsa-mir-224-5p ; hsa-mir-548an ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-4313 ; hsa-mir-670-5p ; hsa-mir-3943
Nearest miRNA
hsa-mir-1253/Upstream/33668; hsa-mir-10226/Downstream/493215;
Nearest TSS
ENST00000595228/Upstream/10597; ENST00000354746/Downstream/1350;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/6925, chr17-CpG: 73/Downstream/124254
Nearest cancer related gene
TOM1L2(TSG, No orient, 0)
Upstream sequence
CAGACACGGTGGCATTTCCATGGAAACACAGGTGTGCAGGCCGTGTGGAGCTGGGGATGTAGGAGTGGCCAGTGCCCGGTGTCCACGGGGTGCGAGCGGG
Downstream sequence
GACCCGCCATCTGGGGAGGCAAACCACAGAGCTGCTCACAGGGCGAAGAGGGCATCCTCTGACCGCTCTGGCTTCTTCCGGCCAGAAGGGTTTGAGGCTG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate