Basic Information
VIS ID
TVIS44033597
Fusion event
HTLV-1-CACHD1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
NCBI36/hg18
Start
64741145/64502874 (Hg38)
End
64741145/64502874 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
CACHD1
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-324-5p ; hsa-mir-185-5p ; hsa-let-7c-5p ; hsa-mir-6875-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-4778-3p
Nearest miRNA
hsa-mir-12132/Upstream/1175890; hsa-mir-101-1/Downstream/76973;
Nearest TSS
ENST00000473358/Upstream/32082; ENST00000486580/Downstream/3041;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/31943, chr1-CpG: 24/Downstream/2801
Upstream sequence
AACTGCAATTAAAACCACTTAACCTGTAGTTACATTTCCCAAACCCAAGTGGCAGCCTTAAAACTGACCACTGAATTATGGAAACTGAACGGAAAAAGGC
Downstream sequence
TTTGTTTCATTGCATCGAAGTATTTTTCTTTTCCCATTTTGGGTGCATTGATCTCCCTGTATTCCCTGGGGTTGCTGGAAAAACTTGGTCAAAAAGGATA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate