Basic Information
VIS ID
TVIS44033689
Fusion event
HTLV-1-ARRB1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
NCBI36/hg18
Start
74692363/75303671 (Hg38)
End
74692363/75303671 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
ARRB1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-186-5p ; hsa-mir-92a-3p ; hsa-mir-525-3p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6126 ; hsa-mir-491-5p ; hsa-mir-92a-2-5p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-6804-5p ; hsa-mir-3913-3p ; hsa-mir-605-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-4779 ; hsa-mir-574-5p ; hsa-mir-568 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-642a-5p ; hsa-mir-3140-3p ; hsa-mir-6859-3p ; hsa-mir-4469 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6887-3p ; hsa-mir-4640-3p
Nearest miRNA
hsa-mir-10392/Upstream/583334; hsa-let-7a-2/Downstream/31421;
Nearest TSS
ENST00000527297/Upstream/1; ENST00000534555/Downstream/3038;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/61225, chr11-CpG: 97/Downstream/47509
Upstream sequence
AATCTCTGGGCCTGGGGCTGTTTTTACCTGCAGAAGGTACAGGCCCCGGTGTCGGTGTTGTTTCCCCAGAGCACCTACAGGGCAGCGGAAGGCAGACACT
Downstream sequence
CAGTGAACAAGCAAGCCCTCCCTCAAAAGCACAGTGGGAGGGTGGGAGGAGGTGCATGTGTGATGTGCCCAGTTCCGTTCCAGGCACCACCAGGCACCCA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate