Basic Information
VIS ID
TVIS44033743
Fusion event
HTLV-1-SENP1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr12
Cytoband
q13.11
Reference genome
NCBI36/hg18
Start
46728970/48048920 (Hg38)
End
46728970/48048920 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
SENP1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-375 ; hsa-mir-133a-3p ; hsa-mir-183-5p ; hsa-mir-34a-5p ; hsa-mir-192-5p ; hsa-mir-18a-3p ; hsa-mir-138-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-1277-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-5580-3p ; hsa-mir-590-3p ; hsa-mir-3191-5p ; hsa-mir-5571-5p ; hsa-mir-6885-3p ; hsa-mir-5579-3p ; hsa-mir-4694-5p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-5009-3p ; hsa-mir-3124-3p ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-208b-5p ; hsa-mir-208a-5p ; hsa-mir-4768-3p ; hsa-mir-1264 ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-145-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/684651; hsa-let-7i/Downstream/83877;
Nearest TSS
ENST00000382841/Upstream/8159; ENST00000546755/Downstream/16760;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/43331, chr12-CpG: 65/Downstream/56760
Upstream sequence
ctttctctcaataatcaagggaacatgtagaactactactcactaccctctgtgtGTTCTATAAGTACATAGCTTTTACATTTTATCAAAAATGAAAGGG
Downstream sequence
GTACTCACAGCTAGACACCAGTGTACTCCCAGGTGAATGGGCACCAAAAGAATGTCAACAGAAAATACATCTACTTTCTTTGTCCAACGTTTCACTGCCT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate