Basic Information
VIS ID
TVIS44033754
Fusion event
HTLV-1-GYS1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
NCBI36/hg18
Start
54163843/48968774 (Hg38)
End
54163843/48968774 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
GYS1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-122-5p ; hsa-mir-26b-5p ; hsa-mir-516b-5p ; hsa-mir-3191-5p ; hsa-mir-6873-3p ; hsa-mir-7111-3p ; hsa-mir-6081 ; hsa-mir-324-5p ; hsa-mir-20a-3p ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-518c-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-2276-5p ; hsa-mir-5196-3p ; hsa-mir-27a-3p ; hsa-mir-27b-3p
Nearest miRNA
hsa-mir-10395/Upstream/1741753; hsa-let-7e/Downstream/41132;
Nearest TSS
ENST00000633603/Upstream/3473; ENST00000598768/Downstream/1935;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/2655, chr19-CpG: 36/Downstream/491
Upstream sequence
CCGGATGGAGGGATCCTCCAGGCAGAGCCTGGCTCTGACATGCCAGGGAGGGCTAGAACATCCCTCCCAGAGCCCCACTTCTGGAGTTGAAATGGAGGAC
Downstream sequence
CATCTGCTCTCAGTTACCTTCAAACTCTGAAAGTGCCCCGGCTCTGGACTTGATCGCCCCATTCGCAGGGACACCACGTGGTTTCCAGAACTTGGTGGCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate