VISDB - VIS Detail

Basic Information

VIS ID

TVIS44033771

Fusion event

HTLV-1-PAG1 integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr8

Cytoband

q21.13

Reference genome

NCBI36/hg18

Start

82184582/81109792 (Hg38)

End

82184582/81109792 (Hg38)

Orient

Location type

Intronic

Target gene

PAG1

miRNAs that regulate target gene

hsa-mir-103a-3p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-373-5p ; hsa-mir-616-5p ; hsa-mir-371b-5p ; hsa-mir-5003-5p ; hsa-mir-6867-5p ; hsa-mir-6835-3p ; hsa-mir-5010-3p ; hsa-mir-592 ; hsa-mir-597-5p ; hsa-mir-668-3p ; hsa-mir-5087 ; hsa-mir-6831-3p ; hsa-mir-5585-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-329-5p ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-4422 ; hsa-mir-195-5p ; hsa-mir-15a-5p ; hsa-mir-424-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-15b-5p ; hsa-mir-107 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-574-5p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-640 ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-371a-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6513-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-138-1-3p ; hsa-mir-3074-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-513b-5p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-3124-3p ; hsa-mir-512-5p ; hsa-mir-10b-3p ; hsa-mir-4539 ; hsa-mir-498 ; hsa-mir-1303 ; hsa-mir-2681-5p ; hsa-mir-4703-3p ; hsa-mir-556-3p ; hsa-mir-561-3p

Nearest miRNA

hsa-mir-12123/Upstream/868319; hsa-mir-10400/Downstream/10095693;

Nearest TSS

ENST00000518652/Upstream/39616; ENST00000519412/Downstream/2276;

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/215700, chr8-CpG: 70/Downstream/1828

Upstream sequence

atatgccagatactggcccaacagctctatgtctatgaactcatttaattctcactactgttcagtggggtaggtactactactgtcatccccattgtac

Downstream sequence

agatgaagacactgaggcacagactttgggttacttgcctagattcaaacagatggtaccagagctggcagcctggctccatagcctgtcctcctaacca

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.