Basic Information
VIS ID
TVIS44033843
Fusion event
HTLV-1-ARHGAP15 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q22.2
Reference genome
NCBI36/hg18
Start
143813143/143339104 (Hg38)
End
143813143/143339104 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
ARHGAP15
miRNAs that regulate target gene
hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-6807-5p ; hsa-mir-4698 ; hsa-mir-586 ; hsa-mir-5700 ; hsa-mir-3662 ; hsa-mir-4764-3p ; hsa-mir-3134 ; hsa-mir-4495 ; hsa-mir-1246 ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426 ; hsa-mir-8087 ; hsa-mir-6750-3p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa
Nearest miRNA
hsa-mir-128-1/Upstream/2752419; hsa-mir-10b/Downstream/5991174;
Nearest TSS
ENST00000437798/Upstream/91814; ENST00000548800/Downstream/96160;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1208120, chr2-CpG: 111/Downstream/597659
Upstream sequence
GTATGAGGTAATGTGTTCTTTGTTGGGGATAGCTATCCATTTTTtttcataaatattgattgaatgcccattatatgtcagacTTGATTCTAAAGGATAT
Downstream sequence
GCCCCTTAAATGTCATGCCAACTTCTAATATTTAATTAAAGAGCAGGAAAGGGCCTGTTGTTTTTGTTGCTGTGGTTGTTGACTGtagcggagtgttggg
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate