| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30015814 | HIV | ENSG00000055332.19 | protein_coding | EIF2AK2 | No | No | 5610 | P19525 Q8IW76 |
| TVIS20001219 | HPV | ENSG00000055332.19 | protein_coding | EIF2AK2 | No | No | 5610 | P19525 Q8IW76 |
| TVIS44037892 | HTLV-1 | ENSG00000055332.19 | protein_coding | EIF2AK2 | No | No | 5610 | P19525 Q8IW76 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | EIF2AK2 |
|---|---|
| DrugBank ID | DB00328 |
| Drug Name | Indomethacin |
| Target ID | BE0009434 |
| UniProt ID | P19525 |
| Regulation Type | inducer |
| PubMed IDs | 22268531; 25856684 |
| Citations | Brunelli C, Amici C, Angelini M, Fracassi C, Belardo G, Santoro MG: The non-steroidal anti-inflammatory drug indomethacin activates the eIF2alpha kinase PKR, causing a translational block in human colorectal cancer cells. Biochem J. 2012 Apr 15;443(2):379-86. doi: 10.1042/BJ20111236.@@Amici C, La Frazia S, Brunelli C, Balsamo M, Angelini M, Santoro MG: Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2alpha kinase PKR. Cell Microbiol. 2015 Sep;17(9):1391-404. doi: 10.1111/cmi.12446. Epub 2015 May 13. |
| Groups | Approved; Investigational |
| Direct Classification | Benzoylindoles |
| SMILES | COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(O)=O |
| Pathways | Indomethacin Action Pathway |
| PharmGKB | PA449982 |
| ChEMBL | CHEMBL6 |
