| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30042694 | HIV | ENSG00000129219.14 | protein_coding | PLD2 | No | No | 5338 | O14939 |
| TVIS20053236 | HPV | ENSG00000129219.14 | protein_coding | PLD2 | No | No | 5338 | O14939 |
| TVIS20017710 | HPV | ENSG00000129219.14 | protein_coding | PLD2 | No | No | 5338 | O14939 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PLD2 |
|---|---|
| DrugBank ID | DB00122 |
| Drug Name | Choline |
| Target ID | BE0002179 |
| UniProt ID | O14939 |
| Regulation Type | product of |
| PubMed IDs | 16179605; 16459925; 17627030; 16921342; 16878701 |
| Citations | Lee JS, Kim JH, Jang IH, Kim HS, Han JM, Kazlauskas A, Yagisawa H, Suh PG, Ryu SH: Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity. J Cell Sci. 2005 Oct 1;118(Pt 19):4405-13.@@Singh AT, Frohman MA, Stern PH: Parathyroid hormone stimulates phosphatidylethanolamine hydrolysis by phospholipase D in osteoblastic cells. Lipids. 2005 Nov;40(11):1135-40.@@Paruch S, Heinis M, Lemay J, Hoeffel G, Maranon C, Hosmalin A, Perianin A: CCR5 signaling through phospholipase D involves p44/42 MAP-kinases and promotes HIV-1 LTR-directed gene expression. FASEB J. 2007 Dec;21(14):4038-46. Epub 2007 Jul 12.@@Szumilo M, Rahden-Staron I: [Phospholipase D in mammalian cells: structure, properties, physiological and pathological role]. Postepy Hig Med Dosw (Online). 2006;60:421-30.@@Fensome-Green A, Cockcroft S: Reconstitution system based on cytosol-depleted cells to study the regulation of phospholipase D. Methods Mol Biol. 2006;332:299-310. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Cholines |
| SMILES | C[N+](C)(C)CCO |
| Pathways | Phosphatidylcholine Biosynthesis PC(14:0/20:0); Phosphatidylcholine Biosynthesis PC(14:0/20:4(5Z,8Z,11Z,14Z)); Phosphatidylcholine Biosynthesis PC(15:0/20:3(8Z,11Z,14Z)); Phosphatidylcholine Biosynthesis PC(15:0/16:0); Phosphatidylcholine Biosynthesis PC(14:0/20:5(5Z,8Z,11Z,14Z,17Z)); Phosphatidylcholine Biosynthesis PC(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); Phosphatidylcholine Biosynthesis PC(14:1(9Z)/16:0); Phosphatidylcholine Biosynthesis PC(14:0/20:2(11Z,14Z)); Phosphatidylcholine Biosynthesis PC(14:1(9Z)/16:1(9Z)); Phosphatidylcholine Biosynthesis PC(14:1(9Z)/22:2(13Z,16Z)); Phosphatidylcholine Biosynthesis PC(14:1(9Z)/24:0); Phosphatidylcholine Biosynthesis PC(14:0/15:0); Phosphatidylcholine Biosynthesis PC(15:0/14:0); Phosphatidylcholine Biosynthesis PC(15:0/20:4(5Z,8Z,11Z,14Z)); Phosphatidylcholine Biosynthesis PC(15:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); Betaine Metabolism; Phosphatidylcholine Biosynthesis PC(14:0/20:1(11Z)); Phosphatidylcholine Biosynthesis PC(16:0/14:0); Phosphatidylcholine Biosynthesis PC(15:0/22:0); Phosphatidylcholine Biosynthesis PC(14:0/22:5(4Z,7Z,10Z,13Z,16Z)); Phosphatidylcholine Biosynthesis PC(15:0/16:1(9Z)); Phosphatidylcholine Biosynthesis PC(14:1(9Z)/14:0); Phosphatidylcholine Biosynthesis PC(15:0/20:1(11Z)); Phosphatidylcholine Biosynthesis PC(14:0/18:2(9Z,12Z)); Phosphatidylcholine Biosynthesis PC(14:0/14:0); Cystathionine beta-Synthase Deficiency; Phosphatidylcholine Biosynthesis PC(14:0/16:1(9Z)); Phosphatidylcholine Biosynthesis PC(15:0/18:0); Sarcosine Oncometabolite Pathway; Phosphatidylcholine Biosynthesis PC(14:1(9Z)/18:3(9Z,12Z,15Z)) |
| PharmGKB | PA448976 |
| ChEMBL | CHEMBL920 |
