| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10047639 | HBV | ENSG00000073734.10 | protein_coding | ABCB11 | No | No | 8647 | O95342 |
| TVIS10047640 | HBV | ENSG00000073734.10 | protein_coding | ABCB11 | No | No | 8647 | O95342 |
| TVIS30012763 | HIV | ENSG00000073734.10 | protein_coding | ABCB11 | No | No | 8647 | O95342 |
| TVIS20066566 | HPV | ENSG00000073734.10 | protein_coding | ABCB11 | No | No | 8647 | O95342 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | ABCB11 |
|---|---|
| DrugBank ID | DB01016 |
| Drug Name | Glyburide |
| Target ID | BE0000703 |
| UniProt ID | O95342 |
| Regulation Type | inhibitor |
| PubMed IDs | 12404239; 15465654; 15618715 |
| Citations | Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58.@@Kemp DC, Brouwer KL: Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure. Toxicol In Vitro. 2004 Dec;18(6):869-77.@@Horikawa M, Kato Y, Tyson CA, Sugiyama Y: Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Drug Metab Pharmacokinet. 2003;18(1):16-22. |
| Groups | Approved |
| Direct Classification | Benzenesulfonamides |
| SMILES | COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1 |
| Pathways | Glibenclamide Action Pathway |
| PharmGKB | PA449782 |
| ChEMBL | CHEMBL472 |
