| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30049574 | HIV | ENSG00000115758.14 | protein_coding | ODC1 | No | No | 4953 | P11926 |
| TVIS30049575 | HIV | ENSG00000115758.14 | protein_coding | ODC1 | No | No | 4953 | P11926 |
| TVIS20045307 | HPV | ENSG00000115758.14 | protein_coding | ODC1 | No | No | 4953 | P11926 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ODC1 |
|---|---|
| DrugBank ID | DB00127 |
| Drug Name | Spermine |
| Target ID | BE0000404 |
| UniProt ID | P11926 |
| Regulation Type | product of |
| PubMed IDs | 10698696; 10712236; 11160858; 11408092; 11413269; 21413019 |
| Citations | Nilsson J, Grahn B, Heby O: Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression. Biochem J. 2000 Mar 15;346 Pt 3:699-704.@@Ray RM, Viar MJ, Yuan Q, Johnson LR: Polyamine depletion delays apoptosis of rat intestinal epithelial cells. Am J Physiol Cell Physiol. 2000 Mar;278(3):C480-9.@@Korhonen VP, Niiranen K, Halmekyto M, Pietila M, Diegelman P, Parkkinen JJ, Eloranta T, Porter CW, Alhonen L, Janne J: Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8.@@Rohn G, Els T, Hell K, Ernestus RI: Regional distribution of ornithine decarboxylase activity and polyamine levels in experimental cat brain tumors. Neurochem Int. 2001 Aug;39(2):135-40.@@Ernestus RI, Rohn G, Schroder R, Els T, Klekner A, Paschen W, Klug N: Polyamine metabolism in brain tumours: diagnostic relevance of quantitative biochemistry. J Neurol Neurosurg Psychiatry. 2001 Jul;71(1):88-92.@@Lee NK, MacLean HE: Polyamines, androgens, and skeletal muscle hypertrophy. J Cell Physiol. 2011 Jun;226(6):1453-60. doi: 10.1002/jcp.22569. |
| Groups | Experimental; Nutraceutical |
| Direct Classification | Dialkylamines |
| SMILES | NCCCNCCCCNCCCN |
| Pathways | Spermidine and Spermine Biosynthesis |
| PharmGKB | PA164781199 |
| ChEMBL | CHEMBL23194 |
