| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30019224 | HIV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20017037 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20017038 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20016521 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20065407 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20017039 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20050473 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS20017040 | HPV | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
| TVIS44008296 | HTLV-1 | ENSG00000111319.13 | protein_coding | SCNN1A | No | No | 6337 | P37088 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SCNN1A |
|---|---|
| DrugBank ID | DB00594 |
| Drug Name | Amiloride |
| Target ID | BE0000190 |
| UniProt ID | P37088 |
| Regulation Type | inhibitor |
| PubMed IDs | 12928313; 15084585; 17556672; 11752352 |
| Citations | Kelly O, Lin C, Ramkumar M, Saxena NC, Kleyman TR, Eaton DC: Characterization of an amiloride binding region in the alpha-subunit of ENaC. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1279-90. Epub 2003 Aug 19.@@Ji HL, Benos DJ: Degenerin sites mediate proton activation of deltabetagamma-epithelial sodium channel. J Biol Chem. 2004 Jun 25;279(26):26939-47. Epub 2004 Apr 14.@@Otulakowski G, Duan W, Gandhi S, O'brodovich H: Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia. Am J Respir Cell Mol Biol. 2007 Oct;37(4):457-66. Epub 2007 Jun 7.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved |
| Direct Classification | Aminopyrazines |
| SMILES | NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N |
| Pathways | Amiloride Action Pathway |
| PharmGKB | PA448368 |
| ChEMBL | CHEMBL945 |
