| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30008025 | HIV | ENSG00000101162.4 | protein_coding | TUBB1 | No | No | 81027 | Q9H4B7 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | TUBB1 |
|---|---|
| DrugBank ID | DB01229 |
| Drug Name | Paclitaxel |
| Target ID | BE0000026 |
| UniProt ID | Q9H4B7 |
| Regulation Type | inhibitor |
| PubMed IDs | 17139284; 17016423; 19575780; 1350385; 17314054 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Cheung CH, Chen HH, Kuo CC, Chang CY, Coumar MS, Hsieh HP, Chang JY: Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers. Mol Cancer. 2009 Jul 3;8:43. doi: 10.1186/1476-4598-8-43.@@Horwitz SB: Mechanism of action of taxol. Trends Pharmacol Sci. 1992 Apr;13(4):134-6.@@Kovacs P, Csaba G, Pallinger E, Czaker R: Effects of taxol treatment on the microtubular system and mitochondria of Tetrahymena. Cell Biol Int. 2007 Jul;31(7):724-32. Epub 2007 Jan 14. |
| Groups | Approved; Vet_approved |
| Direct Classification | Taxanes and derivatives |
| SMILES | [H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)C4=CC=CC=C4)C4=CC=CC=C4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |
| Pathways | Paclitaxel Action Pathway |
| PharmGKB | PA450761 |
| ChEMBL | CHEMBL428647 |
