| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20000082 | HPV | ENSG00000068078.20 | protein_coding | FGFR3 | Yes | No | 2261 | P22607 Q0IJ44 |
| TVIS20007360 | HPV | ENSG00000068078.20 | protein_coding | FGFR3 | Yes | No | 2261 | P22607 Q0IJ44 |
| TVIS20027601 | HPV | ENSG00000068078.20 | protein_coding | FGFR3 | Yes | No | 2261 | P22607 Q0IJ44 |
| TVIS20027588 | HPV | ENSG00000068078.20 | protein_coding | FGFR3 | Yes | No | 2261 | P22607 Q0IJ44 |
| TVIS20015105 | HPV | ENSG00000068078.20 | protein_coding | FGFR3 | Yes | No | 2261 | P22607 Q0IJ44 |
| TVIS20019576 | HPV | ENSG00000068078.20 | protein_coding | FGFR3 | Yes | No | 2261 | P22607 Q0IJ44 |
| TVIS20019577 | HPV | ENSG00000068078.20 | protein_coding | FGFR3 | Yes | No | 2261 | P22607 Q0IJ44 |
| TVIS20030913 | HPV | ENSG00000068078.20 | protein_coding | FGFR3 | Yes | No | 2261 | P22607 Q0IJ44 |
| TVIS44013030 | HTLV-1 | ENSG00000068078.20 | protein_coding | FGFR3 | Yes | No | 2261 | P22607 Q0IJ44 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | FGFR3 |
|---|---|
| DrugBank ID | DB08901 |
| Drug Name | Ponatinib |
| Target ID | BE0002133 |
| UniProt ID | P22607 |
| Regulation Type | inhibitor |
| PubMed IDs | 23468082 |
| Citations | Gozgit JM, Squillace RM, Wongchenko MJ, Miller D, Wardwell S, Mohemmad Q, Narasimhan NI, Wang F, Clackson T, Rivera VM: Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models. Cancer Chemother Pharmacol. 2013 May;71(5):1315-23. doi: 10.1007/s00280-013-2131-z. Epub 2013 Mar 7. |
| Groups | Approved; Investigational |
| Direct Classification | Benzanilides |
| SMILES | CN1CCN(CC2=CC=C(NC(=O)C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C)C=C3)C=C2C(F)(F)F)CC1 |
| Pathways | Ponatinib Inhibition of BCR-ABL |
| PharmGKB | PA165980594 |
| ChEMBL | CHEMBL1171837 |
