| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20028633 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS20027872 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS20070100 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS20027871 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS20069680 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS44022884 | HTLV-1 | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS44022885 | HTLV-1 | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS44020006 | HTLV-1 | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS44049194 | HTLV-1 | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS44045896 | HTLV-1 | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | LYN |
|---|---|
| DrugBank ID | DB06616 |
| Drug Name | Bosutinib |
| Target ID | BE0004315 |
| UniProt ID | P07948 |
| Regulation Type | inhibitor |
| PubMed IDs | 30969999; 23493838 |
| Citations | Berndt S, Gurevich VV, Iverson TM: Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase. PLoS One. 2019 Apr 10;14(4):e0215140. doi: 10.1371/journal.pone.0215140. eCollection 2019.@@Amsberg GK, Koschmieder S: Profile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemia. Onco Targets Ther. 2013;6:99-106. doi: 10.2147/OTT.S19901. Epub 2013 Mar 4. |
| Groups | Approved |
| Direct Classification | 4-aminoquinolines |
| SMILES | COC1=CC(NC2=C(C=NC3=CC(OCCCN4CCN(C)CC4)=C(OC)C=C23)C#N)=C(Cl)C=C1Cl |
| Pathways | Bosutinib Inhibition of BCR-ABL |
| PharmGKB | |
| ChEMBL | CHEMBL288441 |
