| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20015457 | HPV | ENSG00000135446.17 | protein_coding | CDK4 | Yes | No | 1019 | P11802 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CDK4 |
|---|---|
| DrugBank ID | DB11730 |
| Drug Name | Ribociclib |
| Target ID | BE0002216 |
| UniProt ID | P11802 |
| Regulation Type | antagonist |
| PubMed IDs | 24045179 |
| Citations | Rader J, Russell MR, Hart LS, Nakazawa MS, Belcastro LT, Martinez D, Li Y, Carpenter EL, Attiyeh EF, Diskin SJ, Kim S, Parasuraman S, Caponigro G, Schnepp RW, Wood AC, Pawel B, Cole KA, Maris JM: Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82. doi: 10.1158/1078-0432.CCR-13-1675. Epub 2013 Sep 17. |
| Groups | Approved; Investigational |
| Direct Classification | Pyridinylpiperazines |
| SMILES | CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(C=N3)N3CCNCC3)N=C2N1C1CCCC1 |
| Pathways | |
| PharmGKB | PA166153470 |
| ChEMBL | CHEMBL3545110 |
