| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30018224 | HIV | ENSG00000125166.13 | protein_coding | GOT2 | No | No | 2806 | P00505 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GOT2 |
|---|---|
| DrugBank ID | DB00151 |
| Drug Name | Cysteine |
| Target ID | BE0000383 |
| UniProt ID | P00505 |
| Regulation Type | substrate |
| PubMed IDs | 7612304; 12137566; 30151069 |
| Citations | Gaskin PJ, Adcock HJ, Buckberry LD, Teesdale-Spittle PH, Shaw PN: The C-S lysis of L-cysteine conjugates by aspartate and alanine aminotransferase enzymes. Hum Exp Toxicol. 1995 May;14(5):422-7. doi: 10.1177/096032719501400506.@@Cooper AJ, Bruschi SA, Iriarte A, Martinez-Carrion M: Mitochondrial aspartate aminotransferase catalyses cysteine S-conjugate beta-lyase reactions. Biochem J. 2002 Nov 15;368(Pt 1):253-61. doi: 10.1042/BJ20020531.@@Wen YD, Wang H, Zhu YZ: The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease. Oxid Med Cell Longev. 2018 Jul 29;2018:4010395. doi: 10.1155/2018/4010395. eCollection 2018. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Cysteine and derivatives |
| SMILES | N[C@@H](CS)C(O)=O |
| Pathways | Amiloride Action Pathway; gamma-Glutamyltranspeptidase Deficiency; 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency; Hydroflumethiazide Action Pathway; Bumetanide Action Pathway; Polythiazide Action Pathway; Ethacrynic Acid Action Pathway; Cyclothiazide Action Pathway; Trichlormethiazide Action Pathway; gamma-Glutamyltransferase Deficiency; Methionine Adenosyltransferase Deficiency; Glutamate Metabolism; Chlorothiazide Action Pathway; Pantothenate and CoA Biosynthesis; Non-Ketotic Hyperglycinemia; 2-Hydroxyglutric Aciduria (D and L Form); Indapamide Action Pathway; Hyperinsulinism-Hyperammonemia Syndrome; Iminoglycinuria; Taurine and Hypotaurine Metabolism; Glycine and Serine Metabolism; Chlorthalidone Action Pathway; Bendroflumethiazide Action Pathway; Methionine Metabolism; Eplerenone Action Pathway; Cystathionine beta-Synthase Deficiency; Glucose Transporter Defect (SGLT2); Spironolactone Action Pathway; Sarcosinemia; Quinethazone Action Pathway |
| PharmGKB | PA449173 |
| ChEMBL | CHEMBL863 |
