| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30017655 | HIV | ENSG00000176974.22 | protein_coding | SHMT1 | No | No | 6470 | P34896 |
| TVIS20033629 | HPV | ENSG00000176974.22 | protein_coding | SHMT1 | No | No | 6470 | P34896 |
| TVIS44042347 | HTLV-1 | ENSG00000176974.22 | protein_coding | SHMT1 | No | No | 6470 | P34896 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SHMT1 |
|---|---|
| DrugBank ID | DB01055 |
| Drug Name | Mimosine |
| Target ID | BE0000331 |
| UniProt ID | P34896 |
| Regulation Type | inhibitor |
| PubMed IDs | 10766749; 11936838; 15531579; 8576220 |
| Citations | Oppenheim EW, Nasrallah IM, Mastri MG, Stover PJ: Mimosine is a cell-specific antagonist of folate metabolism. J Biol Chem. 2000 Jun 23;275(25):19268-74.@@Conti P, Frydas S, Reale M, Barbacane RC, Di Gioacchino M, Felaco M, Trakatellis A: Inhibition of MCP-1 and MIP-2 transcription and translation by mimosine in muscle tissue infected with the parasite Trichinella spiralis. Mol Cell Biochem. 2002 Jan;229(1-2):129-37.@@Perry C, Sastry R, Nasrallah IM, Stover PJ: Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication. J Biol Chem. 2005 Jan 7;280(1):396-400. Epub 2004 Nov 4.@@Lin HB, Falchetto R, Mosca PJ, Shabanowitz J, Hunt DF, Hamlin JL: Mimosine targets serine hydroxymethyltransferase. J Biol Chem. 1996 Feb 2;271(5):2548-56. |
| Groups | Experimental |
| Direct Classification | L-alpha-amino acids |
| SMILES | N[C@@H](CN1C=CC(=O)C(O)=C1)C(O)=O |
| Pathways | |
| PharmGKB | PA164752445 |
| ChEMBL | CHEMBL245416 |
