| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10046591 | HBV | ENSG00000022355.18 | protein_coding | GABRA1 | No | No | 2554 | P14867 |
| TVIS30082845 | HIV | ENSG00000022355.18 | protein_coding | GABRA1 | No | No | 2554 | P14867 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GABRA1 |
|---|---|
| DrugBank ID | DB00898 |
| Drug Name | Ethanol |
| Target ID | BE0000795 |
| UniProt ID | P14867 |
| Regulation Type | agonist |
| PubMed IDs | 17139284; 17016423; 17591544; 11752352; 21262851; 12921221 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Santhakumar V, Wallner M, Otis TS: Ethanol acts directly on extrasynaptic subtypes of GABAA receptors to increase tonic inhibition. Alcohol. 2007 May;41(3):211-21.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Earl DE, Tietz EI: Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther. 2011 Apr;337(1):301-11. doi: 10.1124/jpet.110.178244. Epub 2011 Jan 24.@@Davies M: The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci. 2003 Jul;28(4):263-74. |
| Groups | Approved |
| Direct Classification | Primary alcohols |
| SMILES | CCO |
| Pathways | Disulfiram Action Pathway; Ethanol Degradation |
| PharmGKB | PA448073 |
| ChEMBL | CHEMBL545 |
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